Rashmi Rana
Sir Ganga Ram Hospital, India
Title: Effect of phthalates on reproductive biomarkers of infertile male
Biography
Biography: Rashmi Rana
Abstract
Phthalates are used in personal and consumer products, food packaging materials, and polyvinyl chloride plastics and have been measured in the majority of the general population of the India. Consistent experimental evidence shows that some phthalates are developmental and reproductive toxicants in animals. This study explored the association between environmental levels of phthalates and altered reproductive hormone levels in infertile adult male.
Blood and urine samples were collected from 150 infertile patients & 75 fertile volunteers recruited through Department of Urology, Safdarjung Hospital, New Delhi. Selected phthalates & their metabolites were measured in serum and urine samples by GC-M S& UPLC using NIOSH / OSHA detailed protocol. Linear regression models explored the relationship between specific gravity-adjusted urinary phthalate monoester concentrations and serum levels of reproductive hormones, including Estradiol, Testosterone, AP, LD, GGT and hydroxysteroid dehydrogenase. Although we found significant correlation between several phthalate (DICHP, DMOP, DEHP, BEHIP, DBP and DDIP) compounds and mean ranks of testosterone & estradiol in subject, indicating that steroid hormones were associated with phthalates in Indian population. Thus phthalates and their metabolites might be independent risk factors for male infertility.