Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer


18th Global Summit on Environmental Toxicology and Pharmacology

Singapore City, singapore

Rashmi Rana

Rashmi Rana

Sir Ganga Ram Hospital, India

Title: Effect of phthalates on reproductive biomarkers of infertile male


Biography: Rashmi Rana


Phthalates are used in personal and consumer products, food packaging materials, and polyvinyl chloride plastics and have been measured in the majority of the general population of the India. Consistent experimental evidence shows that some phthalates are developmental and reproductive toxicants in animals. This study explored the association between environmental levels of phthalates and altered reproductive hormone levels in infertile adult male.

Blood and urine samples were collected from 150 infertile patients & 75 fertile volunteers recruited through Department of Urology, Safdarjung Hospital, New Delhi. Selected phthalates & their metabolites were measured in serum and urine samples by GC-M S& UPLC using NIOSH / OSHA detailed protocol. Linear regression models explored the relationship between specific gravity-adjusted urinary phthalate monoester concentrations and serum levels of reproductive hormones, including Estradiol, Testosterone, AP, LD, GGT and hydroxysteroid dehydrogenase. Although we found significant correlation between several phthalate (DICHP, DMOP, DEHP, BEHIP, DBP and DDIP) compounds and mean ranks of testosterone & estradiol in subject, indicating that steroid hormones were associated with phthalates in Indian population. Thus phthalates and their metabolites might be independent risk factors for male infertility.