18^th Global Summit on Environmental Toxicology and Pharmacology September 17-18, 2018 Singapore

Biography:

Nadège Samlan Okémy is a senior lecturer (CAMES) from his rank at the Marien Ngouabi University; teacher of animal physiology at the superior normal school. within the framework of its research, she always had for passion and likeconcern the assumption of responsibility of   population through, medicinal plants. the development, rationalization and revalorization of this ancestral culture marks its scientific motivation. What makes her the author of several articles on the issue of pharmacopoeia and traditional medicine in Congo.  

Abstract:

Medicinal plants are staging a comeback and herbal “renaissance‟ is happening all over the globe. The plant products today symbolise safety in contrast to the synthetics that are regarded as unsafe to human and environment (1). The present study deals with the in vitro anti-inflammatory and anti-arthritic activity in aqueous leaf extracts and ointment of Ageratum conyzoides. The previous phytochemical analysis of aqueous extract of Ageratum conyzoides has indicated the presence of several active phytochemicals such as flavonoids, saponin, tannins, steroids and alkaloids which could support the anti-inflammatory effect (2, 3).  

The toxicology and pharmacology studies proved that, aqueous extract and ointment of this medicinal plant aren’t toxic, no irritation on the skin and rat’s eye. In  effect, they showed a significant  reduction  (p < 0.001 at 100 and 200 mg by wistar rat weight  with  aqueous extract , then 4 and 8 g ointment doses)  the volume edema arthritic induced by  Freud Adjuvant ,  under the right posterior paw of wistar rats. Furthermore This extract plant used without dose dependently, in contrary ointment, who appears more effective with  4g. Also extract aqueous and ointment of Ageratum conyzoides blocked the dolour product by inflammation arthritic and shows a significant antioxidant activity (4, 5).  

Therefore, our studies support the isolation and the use of active constituents from aqueous leaf extract of Ageratum conyzoides in treating inflammations and associated Rheumatism. The proposed formulation with this aqueous extract is also active in acute inflammation. Finally, these results suggest the possibility of the use this preparation the treatment of acute or chronic inflammatory pathology by the Congolese population.

Biography:

Manisha Mehta has her expertise in weight, fat, muscle management and sports nutrition. Her keen interest in food and the way it affects life has driven her extensive studies in the subjects of food technology, packaging technology and nutrition along with food service management systems. The foundation of this presentation is based on the years of experience she has gained while studying as well as successful counseling of hundreds of clients with issues varying from weight management to lifestyle disorders and food intolerances in different settings including hospitals and health centers.

Abstract:

Around 39% of the adult world population is overweight and 13% are obese (WHO). One of the major reasons for this (As per Harvard researchers) is certain food toxins responsible for increasing crave-ability of junk food. Another study suggests the presence of certain chemical obesogens which disrupt the leptin and ghrelin (appetite hormones) also affect the size of adipocytes. Prevalence of polycystic ovarian syndrome is claimed to be varying between 6-10% in various studies including the major ones from National Institute of Health (NIN), Rotterdam and androgen excess society. Thyroid on the other hand is affecting 10% of the population (as per a study conducted in 8 major cities of India) The sedentary lifestyle, convenience foods and improper cooking practices though are to be blamed for the increasing prevalence of all lifestyle disorders but at the same time the increasing exposure to environmental toxins including microbiological, natural food toxins, polymer leaching and its residues including phthalates and bisphenols and the biological magnification of the pesticides across the food chain are all the more responsible for the hormonal imbalances caused by the chemicals mimicking the hormones in the natural biochemical processes hence causing the lifestyle disorders. The purpose of this presentation is to compile and highlight the most common toxins affecting the nutritional status of the masses, their common sources and mode of action. The presentation also puts light on the solution based approach (including the importance of an anti-inflammatory diet) and steps which can be taken to rectify the fundamentals which are going wrong.

Biography:

Fu Chi Chuang is a Graduate student of Institute of Educational Administration and Policy at National Chiayi University. Her study focuses on the elementary school teachers’ in‐service training policy. She also pays close attention to the environmental hormones that risk human health.

Abstract:

As the industrial development, our environment has been contaminated by many artificial chemical, such as plastics, pesticides and so on. Many environmental pollutants that have been classified as environmental hormone (also named endocrine disruptors) and have received much attention over the last 20 years. Environmental protection is the most important issue all over the world and it is the responsibility for all the global citizens. Education is the ways to educate citizens to have correct knowledge and learn how to protect our environment. Elementary education is typically the first stage of formal education and environmental education is an important component for student to help them develop adequate environmental knowledge, attitudes and behavior. However, elementary teachers’ knowledge plays the critical role in such mission. Therefore, we use questionnaire to survey the environmental knowledge (case of environmental hormone) of elementary school teachers and also survey the motivation of environmental hormone regarding knowledge, learning behavior of them. We have collected 107 questionnaires and the results to indicate around 34% elementary school teachers who are not knowledgeable about environmental hormones and its potential risk for health and also indicate the less understanding of environmental hormones which will strengthen their learning motivation.

Biography:

Dr Iadarilang Tiewsoh ,  physician intensivist , did her intensive care medicine from Christian Medical College , Vellore , Tamil Nadu , India, after which she continued  her field of medicine as Assistant Professor in PGIMER ,Chandigarh for a while and joined the Central Medical Institute , North Eastern Indira Gandhi Regional Institute of Medical Sciences , Shillong , Meghalaya , from April , 2017.She has great passion in the field of critical care medicine  which toxicology is a part of it. Having join the present institute she started to encounter the fatal cases of mushroom  poisoning , and has a goal of studying more about to poisoning to help create awareness to the affected areas.

Abstract:

Statement of the problem :Mushroom poisoning has been encountered frequently in the Indian sub-continient and  worldwide . It is known to be one of the cause of fulminant hepatitis for which the definitive treatment being liver transplant .In the case reports reported till date the patients of mushroom poisoning are being diagnosis by  clinical presentations and history of mushroom intake , because the availability of the mycologist and toxicologists required for mushroom identification and diagnosis were not available in many places . Mushroom forms part of the diet in the ethinic tribes of our country and most of the case reports of mushroom poisoning  till date are from North India and South India among the tribes of the areas with the intake of wild mushrooms unintentional. In our little is known about the type of  syndrome presentation in patients  with mushroom poisoning  and little awareness is being provided about the non edible mushroom in this region .

   The purpose of this study is to describe  the clinical presentation of all the patients presenting to the hospital in the last 4 years with mushroom poisoning  where a fair idea of the existing  poisonous  mushroom species can be made from the specified syndrome Methodology :.The hospital records of all  the patients  with a diagnosis of mushroom poisoning  were reviewed from January 2014  to may 2018  and  all relevant information were recorded in a structured performa . A descriptive analysis of all collected variables was carried out . Findings: Over 28 cases of mushroom  poisoning presented to our hospital  in the last 4 years , mainly  in the the raining season (March- May) and autumn season (August –October ) .All cases were from the tribal areas of the four neighbouring 4 districts of the state  .The wild mushrooms were self picked from the forest . 15 patients had developed early symptoms (less than 6 hours ) and were less fatal , however 13 patients developed the symptoms after 6 hours of consumption , and were more seriously ill out of which 4 cases expired due to acute hepatic failure . The clinical syndrome presentation were  acute gastroenteritiswith  liver failure in 8 cases (suspected Aminata poisoning ) , 13 cases of acute gastroenteritis(suspected mushroom species Chlorophyllum molybdites, Clitocybe nebularis, Omphalates illudens ), one case of Acute renal failure (suspected cortinarius violaceus species), one case showing  Disulfiram like reaction (suspected Coprinus atramentarius, Clitocybe clavipes species ) , 5 cases of  Cholinergic mushroom poisoning (suspected Citocybe dealbata C.illudens , Inocybe fastigiata species ). The mortality from mushroom poisoning resulted mainly due to fulminant hepatitis in 4 cases .

Conclusion : The mushroom poisoning  in this part of the country is mainly due to consumption of wild poisonous mushrooms, with  amanita species type being responsible for most of the fatalities . From the clinical syndrome presentation and on  visiting   the affected areas , the aminata species seems to be common , a variety of the other poisonous mushroom are also present as evident from the clinical presentation . The aminata biosporigera and cortinarius violaceus species has been identified at the affected villages .

Biography:

Professor Emmanuel Egwu Oti is a Lecturer in the Department of Fisheries and Aquaculture, Ebonyi State University, Abakaliki Nigeria. His area of specialization is Fish and Aquatic Toxicology. He has numerous publications in Fish and Aquatic Toxicology, Fisheries aquaculture pollution etc in both local and international journals. He is a member of many professional associations such as Aquatic Science Society of Nigeria , Fisheries society of Nigeria among others.

Professor Oti is a recipient of local and international awards such as NOC Research Award, ASUU award for excellence and integrity, Fellow Research and Human Development(FRHD). He is married with children.

Abstract:

The impact of acute exposure of karate (Lambda cyhalothrin pyrethriod) insecticide evaluated during a 4 day exposure period at 20ppm, 40ppm, 60ppm, and 80ppm to “Heteroclarias” fingerlings showed the 96-hlC50 as 25.12ppm. The threshold value was 25.11ppm. the gills of the exposed fish analyzed showed a significant decrease in all the major cataions and ions(Na⁺, Cl^-, Ca²⁺, k⁺, Mg²⁺) at (P<0.05). Although there was no total inhabitation of uptake of the cataions and anions studied, the results revealed that the uptake of these cataions and anions (Na⁺, Cl^-, Ca²⁺, k⁺, Mg²⁺) increased rapidly during the 24hr period and dropped at 48hr and 72hr and gradually increased at the end of the 96^th hr showing that it was time dependent during the exposure period the fish stood in upright position with their snouts above the water level gasping for air. Other behavioral characteristics of the exposed fish were peeling if skin, initial increase of opercula movement, curvature of the body, loss of balance, erratic swimming, quietness and finally death. These results therefore recommend that this insecticide (karate) should be applied appropriately at a recommended dose to avoid damage to both target and non target organisms

Biography:

Abstract:

Water contamination has recently become an increasingly severe and pervasive problem for worldwide and the effluents of textile industries have been recognized as a major polluting source, due to the emission of large amounts of wastewaters. Reactive Red-120 (RR-120) and Reactive Blue Bezaktiv-150 (RBB-150) anionic dyes act specifically as the most hazardous chemical compounds classes that elicit adverse effect on aquatic organisms and humans, and need to be treated. In the present study, magnesium-aluminum layered double hydroxide (MgAl LDH) was used as a selective adsorbent for the successful removal of RR-120 and RBB-150 textile dyes from aqueous solutions. Batch adsorption experiments were carried out to investigate the effect of various operating parameters such as initial concentration of dye, contact time, adsorbent dosage, initial pH and temperature in order to provide optimum removal conditions. XRD, FT-IR, SEM and AFM analyses were used to highlight the assembly LDH−Dye. The adsorption process of RR-120 and RBB-150 was found to be at pH of 5 and temperature dependent and followed the pseudo-second order rate model. Also, the equilibrium adsorption data of both dyes were found to adopt the Langmuirtype isotherm model which assumes a monolayer coverage as the adsorption saturates and no further adsorption occurs. Furthermore, the presence of both dyes in competitive adsorption from binary aqueous solution was demonstrated.

Biography:

Nadège Samlan Okémy is a Senior Lecturer (CAMES) at the Marien Ngouabi University. He is a Teacher of Animal Physiology at the Superior Normal School. Within the framework of research, she always had a passion and concern for the assumption of responsibility of population through, medicinal plants. The development, rationalization and revalorization of this ancestral culture mark its scientific motivation.

Abstract:

Medicinal plants are staging a comeback and herbal renaissance is happening all over the globe. The plant products today symbolize safety in contrast to the synthetics that are regarded as unsafe to human and environment. The present study deals with the in vitro anti-inflammatory and anti-arthritic activity in aqueous leaf extracts and ointment of Ageratum conyzoides. The previous phytochemical analysis of aqueous extract of Ageratum conyzoides has indicated the presence of several active phytochemicals such as flavonoids, saponin, tannins, steroids and alkaloids which could support the anti-inflammatory effect. The toxicology and pharmacology studies proved that, aqueous extract and ointment of this medicinal plant aren’t toxic, no irritation on the skin and rat’s eye. In effect, they showed a significant reduction (p<0.001 at 100 and 200 mg by wistar rat weight with aqueous extract, then 4 and 8 g ointment doses) the volume edema arthritic induced by Freud Adjuvant, under the right posterior paw of wistar rats. Furthermore this extracts plant used without dose dependently, in contrary ointment, which appears more effective with 4 g. Also extract aqueous and ointment of Ageratum conyzoides blocked the dolor product by inflammation arthritic and shows a significant antioxidant activity. Therefore, our studies support the isolation and the use of active constituents from aqueous leaf extract of Ageratum conyzoides in treating inflammations and associated rheumatism. The proposed formulation with this aqueous extract is also active in acute inflammation. Finally, these results suggest the possibility of the use this preparation the treatment of acute or chronic inflammatory pathology by the Congolese population.

Biography:

Dr. Rashmi Rana joined Department of Research, Sir Gangaram Hospital, New Delhi, India as Scientist in Aug 2017 and she did his master in Biomedical Sciences and PhD, Biochemistry from AIIMS, New Delhi, India. She is recently working on Medical Toxicology as toxicology research is primarily to be concerned with three aspects of toxicology: adverse effects of therapeutic agents, acute intoxications, and chronic poisoning/environmental toxicology. The adverse effects of environmental toxicant should be considered along with the Toxicology of individual pollutant or groups of environmental pollutant. She has published 7 international research papers and 1 national and she was elected member of many societies. She is recipient of Three Best Oral presentations award and two Best Poster award, and also awarded travel student award winner of Society of Toxicology PPTOXII conference held in Miami FL, U.S.A, Dec 2008, awarded student winner of air pollution and health conference held in San Diego, California, U.S.A, March 2010.

Abstract:

Phthalates are used in personal and consumer products, food packaging materials, and polyvinyl chloride plastics and have been measured in the majority of the general population of the India. Consistent experimental evidence shows that some phthalates are developmental and reproductive toxicants in animals. This study explored the association between environmental levels of phthalates and altered reproductive hormone levels in infertile adult male.

Blood and urine samples were collected from 150 infertile patients & 75 fertile volunteers recruited through Department of Urology, Safdarjung Hospital, New Delhi. Selected phthalates & their metabolites were measured in serum and urine samples by GC-M S& UPLC using NIOSH / OSHA detailed protocol. Linear regression models explored the relationship between specific gravity-adjusted urinary phthalate monoester concentrations and serum levels of reproductive hormones, including Estradiol, Testosterone, AP, LD, GGT and hydroxysteroid dehydrogenase. Although we found significant correlation between several phthalate (DICHP, DMOP, DEHP, BEHIP, DBP and DDIP) compounds and mean ranks of testosterone & estradiol in subject, indicating that steroid hormones were associated with phthalates in Indian population. Thus phthalates and their metabolites might be independent risk factors for male infertility.

Biography:

Dele Adeniyi is a Research Scientist, Phytopathologist and agricultural consultant affiliated with Cocoa Research Institute of Nigeria. He has both teaching and research experience since 2005 and have been involve in many projects at different levels and discipline. He has expertise and skill in integrated disease management, research interest in toxicity of natural organic products, pesticide screening and chemical residue related issues in food products. He is also trained in plant health strategies for food, nutrition and trade, and value chain promotion and management. To his credit are tens of conference papers and scientific publications in referred journals of international repute. He’s a Fellow of Cocoa Cochran, Netherlands Fellowship Program and Master Trainer, Africa Cashew Alliance/Competitive Cashew initiative.

Abstract:

Aim: The study determines the estimated toxicity and efficacy of copper-based fungicides use to control Phytophthora megakarya

Study Design: Toxicity of fungicides against Phytophthora megakarya was determined in-vitro using mycelial growth inhibition.

Methodology: Isolates of Phytophthora megakarya were collected from cacao plantation in the demonstration/experimental plots of Cocoa Research Institute of Nigeria, Ibadan, South Western Nigeria. Three active ingredients: Cuprous oxide, Copper hydroxide and Copper hydroxide + metalaxyl in fungicides retailed in open market in Ibadan were assayed in-vitro at 0.5 µg/ml, 1.0 µg/ml, 1.5 µg/ml, 2.0 µg/ml and 2.5 µg/ml of active ingredient against mycelial growth of Phytophthora megakarya; pathogen of black pod disease. The antifungal index and effective concentration at which mycelial growth was inhibited by 50% (EC₅₀ value) was calculated for pathogen/fungicide combination and probit analysis.

Results: Toxicity of fungicides against Phytophthora megakarya using the EC₅₀ showed significant variation as estimated from the mycelial growth inhibition. Highest mycelial inhibition (85.25%) of Phytophthora megakarya was recorded at 2.5 µg/ml of Copper hydroxide + metalaxyl with estimated EC₅₀ value of 0.18 µg/ml and highest toxicity was recorded in Copper hydroxide + metalaxyl  while Cuprous oxide was least toxic against Phytopthora megakarya. The toxicity responses of these Copper-based fungicides against Phytophthora megakarya vary with active ingredients and Copper hydroxide + metalaxyl gave the highest fungitoxic effect. 

Biography:

Okereke Chioma Joy had her M.Sc. in Environmental Biochemistry at the University of Port Harcourt Nigeria in 2016. She emerged as the best graduating student in Biochemistry (2012) at the University of Port Harcourt where she is currently a PhD candidate and also working as an assistant lecturer in the department of Biochemistry. She is a full member of the West African Society of Toxicology. Her research interests include environmental and food toxicants.

Abstract:

Children are more susceptible and vulnerable to the adverse health effects of heavy metal pollution due to their small body size, developing nervous system, high absorption rate and behavioral pattern present during childhood. This study was carried out to assess potential health risk of the exposure of school children in Ahoada West Local Government Area in Rivers state, to heavy metal contamination in playground soil. To assess the extent of heavy metal pollution in playground soil, ten soil samples were collected from ten different primary schools and evaluated for heavy metals using Flame Atomic Absorption Spectrophotometer. Results of the study showed that the heavy metals concentration (mg/kg) ranged from 0.01-0.04, 9.08-13.30, 18.00-24.15, 0.12-0.97 and <0.01 for Pb, Cu, Ni, Cr and Cd respectively. Daily dose intakes through oral ingestion of contaminated soil were calculated using United State Environmental Protection Agency (USEPA) model for non-carcinogenic risk assessment. The results ranged from 1.30 x 10^-5 – 6.90 x 10^-5, 3.00 x 10^-4 – 4.40 x 10^-4, 5.90 x 10^-4 – 8.00 x 10^-4, 1.50 x 10^-5 – 4.00 x 10^-5, and 0.00- (mg/kg/day) for Pb, Cu, Ni, Cr and Cd respectively. The results for the non-carcinogenic hazard quotient ranged from 1.30 x 10^-6 – 2.30 x 10^-6, 7.50 x 10^-3 – 1.00 x 10^-2, 3.00 x 10^-4 – 4.00 x 10^-3, 1.3 x 10^-6 – 3.0 x 10^-2 and 0.00 for Pb, Cu, Ni, Cr and Cd respectively. The results suggested that there were no significant heavy metal health risk for the children as the hazard quotient were all below 1.0 in the ten primary schools.

Biography:

Tawfiq Almsatar has his expertise in evaluation and assessing  biomonitoring of air pollutants,  and and passion in improving the health. Able to educate students in environmental toxicology, and industrial pollution.

Abstract:

Air pollution can be defined as a condition in which the concentrations of substances in the atmosphere are high enough to cause measurable effect on man, animals, vegetation or materials. A “substance” , refer to particulate matteer which is any natural or anthropological airborne chemical element or compound that can exist in the atmosphere as gases, liquid drops or solid particles .

Particulate matter(PM)  is a not a single pollutant, but a complex mixture of many types of pollutants, its extremely  made up of acids, organic chemicals, metals, and soil or dust particles , with different physical, chemical and biological characteristics, which determine both its behavior, as well as its environmental and health effects .

Air pollution is a pervasive public health issue with major cardiovascular and health economic consequences, and it should remain a key target for global health policy. The effect of air pollution on other cardiovascular conditions, been less well described .

The World Health Organization (WHO) reported that ambient air pollution was responsible for 3.7 million deaths in 2012, representing 6.7% of total deaths worldwide, and was the cause of 16% of lung cancer deaths, 11% of chronic obstructive pulmonary disease-related death, 29% of heart disease and stroke, and approximately 13% of deaths due to respiratory infection. This article will discuss, the source of particulate matter air pollutants,  the geographical distribution, and its human health impact.     

Biography:

Priyanka Agarwal is pursuing Ph.D. from Dr.B.R.Ambedkar University, Agra under the supervision of Prof. Ajay Taneja and working in environmental toxicology to find out the association of polycyclic aromatic hydrocarbons (PAHs) with birth defects. I have done my M. Phil in 2011, focusing on the impact of particulate matter on the health of petrol pump workers and till then, working in the field of human toxicology. I have attended 10 International and National conferences and have 6 published international papers, focusing on the impact of pesticides, PAHs and metals on birth defects.

Abstract:

As ubiquitous in nature, polycyclic aromatic hydrocarbons (PAHs) receive attention because of their possible role in implicating adverse pregnancy outcomes, including preterm birth, reduced birth weight and intrauterine growth restriction. In this study the association of PAHs exposure with preterm birth was explored by collecting the placental tissue samples after delivery from 84 healthy non-smoking pregnant women. Then PAHs was extracted from samples followed by quantification with the help of gas chromatography equipped with an FID detector (GC-FID). A detailed questionnaire and medical records of pregnant women were also included in the study. Levels of PAHs were compared between two groups, one group with women having gestational age≥37 weeks known as a control group and the second group having a gestational age < 37 week serve as a study group. For most PAHs, higher, but statistically insignificant levels were found in the study group than the control except for acenaphthene, fluorene, acenaphthylene, phenanthrene, benzo(a)anthracene and chrysene. However, significantly higher level of benzo (a) pyrene was found in preterm delivery group (0.485±0.675 ppb) than full term delivery group (0.124±0.436 ppb). The association between PAHs and gestational age was drawn with the help of linear regression model. The values of the Pearson correlation coefficient clearly shown the significant correlation (P<0.05) of benzo (a) pyrene (r=-0.293) and anthracene (r=-0.264) for the depletion trend of gestational age. Also, the standardized PAHs effect was little higher for benzo (a) pyrene (β=-0.549, P<0.001) than that attributed to anthracene (β=-0.303, P<0.05). This finding suggests the possible role of environmental pollutant like PAHs for inducing early delivery in women.

Biography:

Dr. rer. nat. Richard Gminski, is a senior scientist at the Institute of Infection Prevention and Hospital Epidemiology, Medical Center, University of Freiburg, Germany. He holds a degree in pharmacy and was rewarded a doctorate in natural sciences by the University of Heidelberg, Germany. He was scientific assistant in various university departments and medical centers in Heidelberg, Mannheim, Trier, Giessen and Berlin. His current research interests are environmental toxicology and particle toxicology, i.e. molecular mechanisms of fine and ultrafine particles (nanoparticles) with respect to mutagenicity and DNA damage in humans. Further interests are nutrition, forensic medicine and urban global health. He develops new high-throughput assays for rapid screening of biological activity or toxicity of environmental toxins and chemical compounds. He has broad experience in mutagenicity, genotoxicity and carcinogenicity testing of environmental chemicals and has published many papers on these topics.

Abstract:

Despite international efforts to limit worker exposure, coal mine dusts continue to impact the health of thousands of miners across Europe. Modern, practicable assessment tools and devices are urgently needed to protect workers, particularly from the fine fraction (PM_2.5), which is increasingly implicated in human disease. To predict dust toxicity of different coal mine dusts and mining scenarios, a set of toxicological assays are necessary to identify a successful improvement of risk management targeting mitigation measures.

Various studies indicate that the surface area and the potential to form reactive oxidants are highly promising metrics to predict the toxic potency of fine and ultrafine dusts.

 In the frame of the European ROCD project, two lignite coal mine dusts with different fractions (PM_2.5 and PM₁₀) obtained from a coal mine in Velenje (Slovenia) were investigated for their cytotoxic, oxidant generating capacity and inflammatory potential in the human alveolar epithelial cell line A549. Furthermore, to relate the observed effects to the hydroxyl-radical (OH·)-generating activities of these samples. The approach is based on the aligned electron paramagnetic resonance spectroscopy (EPR) technique with 5.5-dimethyl-1-pyrroline-N-oxide (DMPO) as spin trap and hydrogen peroxide as substrate, and is specifically sensitive to Fenton-type reaction mediated generation of hydroxyl radicals.

The results show that the two lignite coal mine dust samples investigated induce cytotoxic effects, produce ROS and release cytokine IL-8 in a concentration-dependent manner, with a similar potency to the two reference substances quartz and coal fly ash (CFA). Moreover, the toxic effects of the two coal mine dusts observed in human lung cells A549 appear to correlate with the hydroxyl-radical-generating capacities of both coal mine dust samples. The two studied coal mine samples and two reference substances with known constituents reveal the intrinsic hydroxyl-radical-generation method to be a sensitive tool for prediction of adverse health effects

Biography:

Dr. Jaskaran Singh has his expertise in evaluation and passion in detection and determination of drugs and other metabolites from forensic samples. His open and contextual analysis model  is based on using various instrumental methods . He has worked on this paper after years of experience in research, evaluation, teaching and administration by both working in forensic science lab and by teaching at university . The foundation is based on formulation of protocol for forensic science lab to detect drugs specially antibiotics from forensic matrices. Since it is very difficult to detect drug in minute quantities from forensic samples. The said topic was chosen as forensic science labs are receiving many antibiotic abuse cases.

Abstract:

An isocratic liquid chromatographic method with UV detection at 242 nm is described for determination of ceftriaxone  . Chromatographic separation of drug was achieved on a Hypersil ODS C-18 150mm X 4.6mm, 5μmcolumn using a mobile phase consisting of a binary mixture of Phosphate buffer (4.5590gm of Potassium dehydrogenate orthophosphate in 1.0 liter Water and pH was adjusted to 7.5) and Methanol in the ratio of 60:40v/v. The developed Liquid Chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for drug. Linearity, accuracy and precision were found to be acceptable over the concentration range of 10-40microgram/ml for ceftriaxone. The LC method can be used for the detection of ceftriaxone overdosage cases found in various forensic matrices like blood, gastric lavage and viscera, and for quality control of formulated products.

Biography:

Manisha Mehta has her expertise in weight, fat, muscle management and Sports Nutrition. Her keen interest in food and the way it affects life has driven her extensive studies in the subjects of Food technology, Packaging Technology and Nutrition along with Food Service management systems. The foundation of this presentation is based on the years of experience she has gained while studying as well as successful counselling of hundreds of clients with issues varying from weight management to lifestyle disorders and food intolerances in different settings including hospitals and health centers.

Abstract:

Around 39% of the adult world population is overweight and 13 % are obese (WHO). One of the major reasons for this (As per Harvard Researchers) is certain food toxins responsible for increasing “craveability” of junk food. Another study suggests the presence of certain chemical obesogens which disrupt the leptin and ghrelin (appetite hormones) also affect the size of adipocytes.

Prevalence of polycystic ovarian syndrome is claimed to be varying between 6-10% in various studies including the major ones from National institute of Health (NIN), Rotterdam and Androgen excess society. Thyroid on the other hand is affecting 10% of the population (as per a study conducted in 8 major cities of India) The sedentary lifestyle, convenience foods & improper cooking practices though are to be blamed for the increasing prevalence of all lifestyle disorders but at the same time the increasing exposure to environmental toxins including microbiological, natural food toxins, polymer leaching and its residues including phthalates and bisphenols and the biological magnification of the pesticides across the food chain are all the more responsible for the hormonal imbalances caused by the chemicals mimicking the hormones in the natural biochemical processes hence causing the lifestyle disorders.

The purpose of this presentation is to compile and highlight the most common toxins affecting the nutritional status of the masses, their common sources and mode of action.

The presentation also puts light on the solution based approach (including the importance of an Anti-inflammatory diet) and steps which can be taken to rectify the fundamentals which are going wrong.

Biography:

Dr. Rifat Ullah Khan is working as one of the extensively involved researcher in the field of poultry nutrition and production. Improved results have been produced as a results of safe feed additives which may act as substitutes to antibiotics. Currently the use of antibiotics have been banned due to its negative impact on the animal and human lives as well as environmental pollution. The use of novel feed additives have been proven substitutes of antibiotics in poultry production for the safe use for the consumers and the environment.

Abstract:

The present study was designed to find the effect of ginger and garlic on the performance and integrity of gut in experimentally induced coccidiosis in broiler chickens. A total of two hundred day-old Hubbard broiler chicks were divided into six equal groups as following: T1, Control (basal diet only); T2, Infected–untreated (positive control); T3, Infected and supplemented with garlic at 15 g/kg feed; T4, Infected and supplemented with gingers at 5 g/kg feed; T5, Infected and treated with amprolium hydrochloride at 1.25 g/liter drinking water; T6, Infected and supplemented with mixture of garlic and ginger at the rate of 2.5 and 7.5 g/kg feed. The results showed that feed intake, body weight and feed conversion ratio (FCR) was significantly (P<0.05) high in ginger and garlic supplemented birds compared to the positive control. Similarly, oocysts shedding, lesion score and histopathology of the small intestines improved in ginger and garlic supplemented birds after induced-infection in broiler. The findings of the present study showed that ginger and garlic produced encouraging results in comparison to amprolium in broiler chickens infected with experimental coccidiosis.